vaccine production method is very progressive. The method of production based on antigen production technology is divided into 4 methods.

First generation vaccines produce traditional vaccines. The conventional method used to produce generic vaccines is:

Killed vaccine or Inactivated vaccine Antigen is derived from the pathogenesis of the disease, such as vaccines, tetanus, cholera, whooping cough, rabies, influenza, and polio vaccines.

Live attenuated vaccine Antigen is derived from the pathogenic to weaken the disease cannot cause disease. For example, measles vaccines, mumps, polio vaccines And vaccines like yellow fever.

Toxoid Antigen is made up of the toxins produced by the pathogen. The toxicity is down, such as tetanus toxins. And the sodium diphosphate


Subunit Vaccine Antigen is derived from the isolation of naturally occurring organisms such as plasma-derived hepatitis B vaccines from the introduction of HBsAg of the hepatitis B virus. Meningococcal polysaccharide and pneumococcus are produced as meningococcal vaccines and pneumococcal vaccines.


Second generation vaccine production Antigen is a piece of germ. Which is produced by the organism? Based on the knowledge of molecular biology and recombination of DNA technology such as yeast-derived recombination hepatitis B vaccine

Third generation vaccine production Antigen is a part of the pathogen. Produced in vitro by chemical and physical processes. Vaccines produced by this method are still under trial.

Fourth generation vaccine production Antigen is the DNA of the pathogen that controls protein production. That can stimulate the body. This vaccine is called a nucleic acid vaccine or a DNA vaccine. The vaccine produced by this method is still under trial.